Neuromodulators effectively decrease the appearance of fine lines and wrinkles while also preventing their progression. These treatments work by temporarily relaxing the underlying muscle activity that contribute to the formation of moderate to severe wrinkles due to facial expressions. In addition to smoothing out forehead lines, frown lines, crows feet, and bunny lines, neuromodulators can also be used to elevate the eyebrows, soften perioral lines and neck bands, improve the appearance of a dimpled chin, and reduce hyperhidrosis. Furthermore, neuromodulators can be used to enhance the appearance of the upper lip and corners of the mouth.